Publications

Publications of the Institute of Cell Biology and Immunology

Publications of the Institute

  1. 2019

    1. Salvucci, M., Rahman, A., Resler, A. J., Udupi, G. M., McNamara, D. A., Kay, E. W., … Prehn, J. H. M. (2019). A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic. JCO Clinical Cancer Informatics, (3), 1--17. https://doi.org/10.1200/CCI.18.00056
    2. Podder, B., Guttà, C., Rožanc, J., Gerlach, E., Feoktistova, M., Panayotova-Dimitrova, D., … Rehm, M. (2019). TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. Cell Death & Differentiation, 1. https://doi.org/10.1038/s41418-019-0315-8
    3. Richter, F., Seifert, O., Herrmann, A., Pfizenmaier, K., & Kontermann, R. E. (2019). Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc. MAbs, 1--13. https://doi.org/10.1080/19420862.2019.1596512
    4. Beha, N., Harder, M., Ring, S., Kontermann, R. E., & Müller, D. (2019). IL-15-based trifunctional antibody-fusion proteins with costimulatory TNF-superfamily ligands in the single-chain format for cancer immunotherapy. Molecular Cancer Therapeutics, molcanther.1204.2018. https://doi.org/10.1158/1535-7163.MCT-18-1204
    5. von Blume, J., & Hausser, A. (2019). Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network. FEBS Letters, 1873--3468.13552. https://doi.org/10.1002/1873-3468.13552
    6. Fischer, R., Padutsch, T., Bracchi-Ricard, V., Murphy, K. L., Martinez, George. F., Delguercio, N., … Bethea, J. R. (2019). Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2019.06.021
    7. Skoko, J., Rožanc, J., Charles, E. M., Alexopoulos, L. G., & Rehm, M. (2019). Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma. BMC Cell Biology, 19(1), 28. https://doi.org/10.1186/s12860-018-0180-1
    8. Kleih, M., Böpple, K., Dong, M., Gaißler, A., Heine, S., Olayioye, M. A., … Essmann, F. (2019). Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death & Disease, 10(11), 851. https://doi.org/10.1038/s41419-019-2081-4
    9. Fischer, R., Sendetski, M., Del Rivero, T., Martinez, G. F., Bracchi-Ricard, V., Swanson, K. A., … Bethea, J. R. (2019). TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes. Proceedings of the National Academy of Sciences of the United States of America, 116(34), 17045--17050. https://doi.org/10.1073/pnas.1902091116
    10. Tsur, N., Kogan, Y., Rehm, M., & Agur, Z. (2019). Response of Patients with Melanoma to Immune Checkpoint Blockade – Insights Gleaned from Analysis of a New Mathematical Mechanistic Model. Journal of Theoretical Biology, 110033. https://doi.org/10.1016/J.JTBI.2019.110033
    11. Seifert, Oliver, Rau, A., Beha, N., Richter, F., & Kontermann, R. E. (2019). Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. MAbs, 19420862.2019.1603024. https://doi.org/10.1080/19420862.2019.1603024
    12. Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., … Olayioye, M. A. (2019). DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes. Journal of Cell Science, jcs.223172. https://doi.org/10.1242/jcs.223172
  2. 2018

    1. Tansi, F. L., Rüger, R., Kollmeier, A. M., Rabenhold, M., Steiniger, F., Kontermann, R. E., … Hilger, I. (2018). Endoglin based  in vivo  near-infrared fluorescence imaging of tumor models in mice using activatable liposomes. Biochimica et Biophysica Acta (BBA) - General Subjects. https://doi.org/10.1016/j.bbagen.2018.03.012
    2. Richter, F., Zettlitz, K. A., Seifert, O., Herrmann, A., Scheurich, P., Pfizenmaier, K., & Kontermann, R. E. (2018). Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity. MAbs, 19420862.2018.1524664. https://doi.org/10.1080/19420862.2018.1524664
    3. Williams, S. K., Fairless, R., Maier, O., Liermann, P. C., Pichi, K., Fischer, R., … Diem, R. (2018). Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific Reports, 8(1), 13628. https://doi.org/10.1038/s41598-018-31957-7
    4. Hantusch, A., Rehm, M., & Brunner, T. (2018). Counting on Death - Quantitative aspects of Bcl-2 family regulation. The FEBS Journal. https://doi.org/10.1111/febs.14516
    5. Rožanc, J., Sakellaropoulos, T., Antoranz, A., Guttà, C., Podder, B., Vetma, V., … Alexopoulos, L. (2018). Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma. Cell Death & Differentiation, 1. https://doi.org/10.1038/s41418-018-0210-8
    6. Chen, M., Urs, M. J., Sánchez-González, I., Olayioye, M. A., Herde, M., & Witte, C.-P. (2018). m6A RNA Degradation Products are Catabolized by an Evolutionarily Conserved N6-methyl-AMP Deaminase in Plant and Mammalian Cells. The Plant Cell, tpc.00236.2018. https://doi.org/10.1105/tpc.18.00236
    7. Del Mistro, G., Lucarelli, P., Müller, I., De Landtsheer, S., Zinoveva, A., Hutt, M., … Kulms, D. (2018). Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma. Npj Systems Biology and Applications, 4(1), 39. https://doi.org/10.1038/s41540-018-0075-y
    8. Jensch, A., Frey, Y., Bitschar, K., Weber, P., Schmid, S., Hausser, A., … Radde, N. E. (2018). The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function. Journal of Biological Chemistry, jbc.RA118.003787. https://doi.org/10.1074/jbc.RA118.003787
    9. Eisler, S. A., Curado, F., Link, G., Schulz, S., Noack, M., Steinke, M., … Hausser, A. (2018). A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions. ELife, 7. https://doi.org/10.7554/eLife.35907
    10. Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., … Kroemer, G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation. https://doi.org/10.1038/s41418-017-0012-4
    11. Lincoln, F. A., Imig, D., Boccellato, C., Juric, V., Noonan, J., Kontermann, R. E., … Rehm, M. (2018). Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death & Disease, 9(11), 1112. https://doi.org/10.1038/s41419-018-1160-2
    12. Fellermeier-Kopf, S., Gieseke, F., Sahin, U., Müller, D., Pfizenmaier, K., & Kontermann, R. E. (2018). Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans. OncoImmunology, 7(9), e1471442. https://doi.org/10.1080/2162402X.2018.1471442
    13. Carberry, S., D’Orsi, B., Monsefi, N., Salvucci, M., Bacon, O., Fay, J., … Prehn, J. M. H. (2018). The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. Cell Death & Disease, 9(2), 125--. https://doi.org/10.1038/s41419-017-0140-2
    14. Siegemund, Martin, Schneider, F., Hutt, M., Seifert, O., Müller, I., Kulms, D., … Kontermann, R. E. (2018). IgG-single-chain TRAIL fusion proteins for tumour therapy. Scientific Reports, 8(1), 7808. https://doi.org/10.1038/s41598-018-24450-8
    15. Apweiler, R., Beissbarth, T., Berthold, M. R., Blüthgen, N., Burmeister, Y., Dammann, O., … Wolkenhauer, O. (2018). Whither systems medicine? Experimental &Amp; Molecular Medicine, 50, e453--. Retrieved from http://dx.doi.org/10.1038/emm.2017.290
    16. Hutt, M., Fellermeier-Kopf, S., Seifert, O., Schmitt, L. C., Pfizenmaier, K., & Kontermann, R. E. (2018). Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells. Oncotarget, 9(13), 11322--11335. https://doi.org/10.18632/oncotarget.24379
    17. Almanza, A., Carlesso, A., Chintha, C., Creedican, S., Doultsinos, D., Leuzzi, B., … Samali, A. (2018). Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications. The FEBS Journal. https://doi.org/10.1111/febs.14608
    18. Satta, A., Mezzanzanica, D., Caroli, F., Frigerio, B., Nicola, M. D., Kontermann, R. E., … Figini, M. (2018). Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells. MAbs, 19420862.2018.1494105. https://doi.org/10.1080/19420862.2018.1494105
    19. Fischer, R., Proske, M., Duffey, M., Stangl, H., Martinez, G. F., Peters, N., … Pfizenmaier, K. (2018). Selective activation of tumor necrosis factor receptor 2 induces anti-inflammatory responses and alleviates experimental arthritis. Arthritis & Rheumatology. https://doi.org/10.1002/art.40413
    20. Crawford, N., Salvucci, M., Hellwig, C. T., Lincoln, F. A., Mooney, R. E., O’Connor, C. L., … Rehm, M. (2018). Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711. Cell Death & Differentiation. https://doi.org/10.1038/s41418-018-0082-y
    21. Hantusch, A., Das, K. K., García-Sáez, A. J., Brunner, T., & Rehm, M. (2018). Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance. Cell Death & Disease, 9(4), 430. https://doi.org/10.1038/s41419-018-0464-6
    22. Puerto-Camacho, P., Amaral, A. T., Lamhamedi-Cherradi, S.-E., Menegaz, B. A., Castillo-Ecija, H., Ordóñez, J. L., … de Álava, E. (2018). Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma. Clinical Cancer Research, clincanres.0936.2018. https://doi.org/10.1158/1078-0432.CCR-18-0936
    23. Danish, L., Imig, D., Allgöwer, F., Scheurich, P., & Pollak, N. (2018). Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps. PLOS ONE, 13(6), 1–19. https://doi.org/10.1371/journal.pone.0198203
  3. 2017

    1. Kuritz, K., Stöhr, D., Pollak, N., & Allgöwer, F. (2017). On the relationship between cell cycle analysis with ergodic principles and age-structured cell population models. Journal of Theoretical Biology, 414, 91--102. https://doi.org/10.1016/j.jtbi.2016.11.024
    2. Strotbek, M., Schmid, S., Sánchez-González, I., Boerries, M., Busch, H., & Olayioye, M. A. (2017). miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. International Journal of Cancer, 140(10), 2310--2320. https://doi.org/10.1002/ijc.30661
    3. Hantusch, A., Brunner, T., Frickey, T., & Rehm, M. (2017). Bcl-2-Ome-a database and interactive web service for dissecting the Bcl-2 interactome. Cell Death and Differentiation, 24(1), 192. https://doi.org/10.1038/cdd.2016.129
    4. Hutt, M., Marquardt, L., Seifert, O., Siegemund, M., Müller, I., Kulms, D., … Kontermann, R. E. (2017). Superior properties of Fc-comprising scTRAIL fusion proteins. Molecular Cancer Therapeutics, 16(12), molcanther.0551.2017. https://doi.org/10.1158/1535-7163.MCT-17-0551
    5. Brinkmann, U., & Kontermann, R. E. (2017). The making of bispecific antibodies. MAbs, 9(2), 182--212. https://doi.org/10.1080/19420862.2016.1268307
    6. Fischer, R., Marsal, J., Guttà, C., Eisler, S. A., Peters, N., Bethea, J. R., … Kontermann, R. E. (2017). Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2. Scientific Reports, 7(1), 6607. https://doi.org/10.1038/s41598-017-06993-4
    7. Schmitt, L. C., Rau, A., Seifert, O., Honer, J., Hutt, M., Schmid, S., … Kontermann, R. E. (2017). Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV. MAbs, 9(5), 831--843. https://doi.org/10.1080/19420862.2017.1319023
    8. Capasso, S., Sticco, L., Rizzo, R., Pirozzi, M., Russo, D., Dathan, N. A., … D’Angelo, G. (2017). Sphingolipid metabolic flow controls phosphoinositide turnover at the \textlessi\textgreatertrans\textless/i\textgreater ‐Golgi network. The EMBO Journal, 36(12), 1736--1754. https://doi.org/10.15252/embj.201696048
    9. Pieper, L. A., Strotbek, M., Wenger, T., Olayioye, M. A., & Hausser, A. (2017). ATF6β-based fine-tuning of the unfolded protein response enhances therapeutic antibody productivity of Chinese hamster ovary cells. Biotechnology and Bioengineering, 114(6), 1310--1318. https://doi.org/10.1002/bit.26263
    10. Sapski, S., Beha, N., Kontermann, R., & Müller, D. (2017). Tumor-targeted costimulation with antibody-fusion proteins improves bispecific antibody-mediated immune response in presence of immunosuppressive factors. OncoImmunology, 6(12), e1361594. https://doi.org/10.1080/2162402X.2017.1361594
    11. Schröder, P., Wagner, A., Stöhr, D., Rehm, M., & Ehlers, W. (2017). Data-driven simulation of metastatic processes within brain tissue. PAMM, 17(1), 221--222. https://doi.org/10.1002/pamm.201710080
    12. Salvucci, M., Urstle, M. L., Morgan, C., Curry, S., Cremona, M., Lindner, A. U., … Prehn, J. H. M. (2017). A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer. Clinical Cancer Research, 23(5), 1200--1212. https://doi.org/10.1158/1078-0432.CCR-16-1084
    13. Lakner, P. H., Monaghan, M. G., Möller, Y., Olayioye, M. A., & Schenke-Layland, K. (2017). Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models. Scientific Reports, 7, 42730. https://doi.org/10.1038/srep42730
    14. Vetma, V., Rozanc, J., Charles, E. M., Hellwig, C. T., Alexopoulos, L. G., & Rehm, M. (2017). Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 25(9), 1489--1494. https://doi.org/10.3727/096504017x14897145996933
    15. Hausser, A., & Schlett, K. (2017). Coordination of AMPA receptor trafficking by Rab GTPases. Small GTPases, 1--14. https://doi.org/10.1080/21541248.2017.1337546
    16. Pieper, L. A., Strotbek, M., Wenger, T., Gamer, M., Olayioye, M. A., & Hausser, A. (2017). Secretory pathway optimization of CHO producer cells by co-engineering of the mitosRNA-1978 target genes CerS2 and Tbc1D20. Metabolic Engineering, 40, 69--79. https://doi.org/10.1016/j.ymben.2017.01.003
  4. 2016

    1. Hendrick, J., Franz-Wachtel, M., Moeller, Y., Schmid, S., Macek, B., & Olayioye, M. A. (2016). The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling. Journal of Cell Science, 129(19), 3583--3596. https://doi.org/10.1242/jcs.190074
    2. Möller, Y., Morkel, M., Schmid, J., Beyes, S., Hendrick, J., Strotbek, M., … Olayioye, M. a. (2016). Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling. Oncotarget, 7(33), 53526--53539. https://doi.org/10.18632/oncotarget.10658
    3. Tansi, F. L., Rüger, R., Böhm, C., Kontermann, R. E., Teichgraeber, U. K., Fahr, A., & Hilger, I. (2016). Potential of activatable FAP-targeting immunoliposomes in intraoperative imaging of spontaneous metastases. Biomaterials, 88, 70--82. https://doi.org/10.1016/j.biomaterials.2016.02.028
    4. Unverdorben, F., Richter, F., Hutt, M., Seifert, O., Malinge, P., Fischer, N., & Kontermann, R. E. (2016). Pharmacokinetic properties of IgG and various Fc fusion proteins in mice. MAbs, 8(1), 120--128. https://doi.org/10.1080/19420862.2015.1113360
    5. Szíber, Z., Liliom, H., Morales, C. O. O., Ignácz, A., Rátkai, A. E., Ellwanger, K., … Schlett, K. (2016). Ras and Rab interactor 1 controls neuronal plasticity by coordinating dendritic filopodial motility and AMPA receptor turnover. Molecular Biology of the Cell, 28(2), mbc.E16--07--0526. https://doi.org/10.1091/mbc.E16-07-0526
    6. Dong, Y., Fischer, R., Naudé, P. J. W., Maier, O., Nyakas, C., Duffey, M., … Eisel, U. L. M. (2016). Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration. Proceedings of the National Academy of Sciences, 113(43), 12304--12309. https://doi.org/10.1073/pnas.1605195113
    7. Fiedler, A., Raeth, S., Theis, F. J., Hausser, A., & Hasenauer, J. (2016). Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints. BMC Systems Biology, 10(1), 80. https://doi.org/10.1186/s12918-016-0319-7
    8. Weyhenmeyer, B. C., Noonan, J., Würstle, M. L., Lincoln, F. A., Johnston, G., Rehm, M., & Murphy, B. M. (2016). Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget, 7(38), 61295--61311. https://doi.org/10.18632/oncotarget.10973
    9. Hendrick, J., & Olayioye, M. A. (2016). Spatial Rho regulation: Molecular mechanisms controlling the GAP protein DLC3. Small GTPases, 1--7. https://doi.org/10.1080/21541248.2016.1260673
    10. Fellermeier, S., Beha, N., Meyer, J. E., Ring, S., Bader, S., Kontermann, R. E., & Müller, D. (2016). Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format. OncoImmunology, 5(11), e1238540. https://doi.org/10.1080/2162402X.2016.1238540
    11. Kälble, F., Damaske, J., Heide, D., Arnold, I., Richter, F., Maier, O., … Ranzinger, J. (2016). Selective blocking of TNF receptor 1 attenuates peritoneal dialysis fluid induced inflammation of the peritoneum in mice. PLoS ONE, 11(10), e0163314. https://doi.org/10.1371/journal.pone.0163314
    12. Siegemund, Martin, Seifert, O., Zarani, M., Dzinić, T., De Leo, V., Göttsch, D., … Kontermann, R. E. (2016). An optimized antibody-single-chain TRAIL fusion protein for cancer therapy. MAbs, 8(5), 879--891. https://doi.org/10.1080/19420862.2016.1172163
    13. Kontermann, R. E. (2016). Half-life extended biotherapeutics. Expert Opinion on Biological Therapy, 16(7), 903--915. https://doi.org/10.1517/14712598.2016.1165661
  5. 2015

    1. Tárnok, K., Gulyás, M., Bencsik, N., Ferenc, K., Pfizenmaier, K., Hausser, A., & Schlett, K. (2015). A new tool for the quantitative analysis of dendritic filopodial motility. Cytometry Part A, 87(1), 89--96. https://doi.org/10.1002/cyto.a.22569
    2. Fernández-Ulibarri, I., Hammer, K., Arndt, M. A. E., Kaufmann, J. K., Dorer, D., Engelhardt, S., … Nettelbeck, D. M. (2015). Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. International Journal of Cancer, 136(9), 2228--2240. https://doi.org/10.1002/ijc.29258
    3. Weber, P., Hornjik, M., Olayioye, M. A., Hausser, A., & Radde, N. E. (2015). A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Systems Biology, 9(1), 9. https://doi.org/10.1186/s12918-015-0147-1
    4. Wortzel, I., Hanoch, T., Porat, Z., Hausser, A., & Seger, R. (2015). Mitotic Golgi translocation of ERK1c is mediated by PI4KIIIβ/14-3-3γ shuttling complex. Journal of Cell Science, 204(22), jcs.170910--. https://doi.org/10.1242/jcs.170910
    5. Kontermann, R. E., & Brinkmann, U. (2015). Bispecific antibodies. Drug Discovery Today, 20(7), 838--847. https://doi.org/10.1016/j.drudis.2015.02.008
    6. Braun, Anja C., & Olayioye, M. A. (2015). Rho regulation: DLC proteins in space and time. Cellular Signalling, 27(8), 1643--1651. https://doi.org/10.1016/j.cellsig.2015.04.003
    7. Fischer, R., Kontermann, R., & Maier, O. (2015). Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy. Antibodies, 4(1), 48--70. https://doi.org/10.3390/antib4010048
    8. Kang, B., Okwieka, P., Schöttler, S., Seifert, O., Kontermann, R. E., Pfizenmaier, K., … Landfester, K. (2015). Tailoring the stealth properties of biocompatible polysaccharide nanocontainers. Biomaterials, 49, 125--134. https://doi.org/10.1016/j.biomaterials.2015.01.042
    9. Bencsik, N., Szíber, Z., Liliom, H., Tárnok, K., Borbély, S., Gulyás, M., … Schlett, K. (2015). Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation. Journal of Cell Biology, 210(5), 771--783. https://doi.org/10.1083/jcb.201501114
    10. Müller, D. (2015). Antibody fusions with immunomodulatory proteins for cancer therapy. Pharmacology and Therapeutics, 154, 57--66. https://doi.org/10.1016/j.pharmthera.2015.07.001
    11. Unverdorben, F., Hutt, M., Seifert, O., & Kontermann, R. E. (2015). A fab-selective immunoglobulin-binding domain from streptococcal protein G with improved half-life extension properties. PLoS ONE, 10(10), e0139838. https://doi.org/10.1371/journal.pone.0139838
    12. Schuster, L., Seifert, O., Vollmer, S., Kontermann, R. E., Schlosshauer, B., & Hartmann, H. (2015). Immunoliposomes for Targeted Delivery of an Antifibrotic Drug. Molecular Pharmaceutics, 12(9), 3146--3157. https://doi.org/10.1021/acs.molpharmaceut.5b00012
    13. Herr, R., Köhler, M., Andrlová, H., Weinberg, F., Möller, Y., Halbach, S., … Brummer, T. (2015). B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Research, 75(1), 216--229. https://doi.org/10.1158/0008-5472.CAN-13-3686
    14. Fischer, R., & Maier, O. (2015). Interrelation of oxidative stress and inflammation in neurodegenerative disease: Role of TNF. Oxidative Medicine and Cellular Longevity, 2015, 1--18. https://doi.org/10.1155/2015/610813
    15. Rabenhold, M., Steiniger, F., Fahr, A., Kontermann, R. E., & Rüger, R. (2015). Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously. Journal of Controlled Release, 201, 56--67. https://doi.org/10.1016/j.jconrel.2015.01.022
    16. Braun, A. C., Hendrick, J., Eisler, S. A., Schmid, S., Hausser, A., & Olayioye, M. A. (2015). The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking. Journal of Cell Science, 128(7), 1386--1399. https://doi.org/10.1242/jcs.163857
  6. 2014

    1. Oesterreich, B., Lorenz, B., Schmitter, T., Kontermann, R., Zenn, M., Zimmermann, B., … Ohlsen, K. (2014). Characterization of the biological anti-staphylococcal functionality of hUK-66 IgG1, ahumanized monoclonal antibody as substantial component for an immunotherapeutic approach. Human Vaccines and Immunotherapeutics, 10(4), 926--937. https://doi.org/10.4161/hv.27692
    2. Jaiswal, M., Dvorsky, R., Amin, E., Risse, S. L., Fansa, E. K., Zhang, S. C., … Ahmadian, M. R. (2014). Functional cross-talk between ras and rho pathways: A ras-specific gtpase-activating protein (p120RasGAP) competitively inhibits the rhogap activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. Journal of Biological Chemistry, 289(10), 6839--6849. https://doi.org/10.1074/jbc.M113.527655
    3. Fischer, R., Wajant, H., Kontermann, R., Pfizenmaier, K., & Maier, O. (2014). Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor. Glia, 62(2), 272--283. https://doi.org/10.1002/glia.22605
    4. Wille, C., Köhler, C., Armacki, M., Jamali, A., Gössele, U., Pfizenmaier, K., … Eiseler, T. (2014). Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases. Molecular Biology of the Cell, 25(3), 324--36. https://doi.org/10.1091/mbc.E13-06-0334
    5. Möller, Y., Siegemund, M., Beyes, S., Herr, R., Lecis, D., Delia, D., … Olayioye, M. A. (2014). EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. PLoS ONE, 9(9), e107165. https://doi.org/10.1371/journal.pone.0107165
    6. Kiesgen, S., Liebers, N., Cremer, M., Arnold, U., Weber, T., Keller, A., … Wu, A. (2014). A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor. Protein Engineering, Design and Selection, 27(10), 331--337. https://doi.org/10.1093/protein/gzu040
    7. Rüger, R., Tansi, F. L., Rabenhold, M., Steiniger, F., Kontermann, R. E., Fahr, A., & Hilger, I. (2014). In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes. Journal of Controlled Release, 186, 1--10. https://doi.org/10.1016/j.jconrel.2014.04.050
    8. Williams, S. K., Maier, O., Fischer, R., Fairless, R., Hochmeister, S., Stojic, A., … Diem, R. (2014). Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis. PLoS ONE, 9(2), e90117. https://doi.org/10.1371/journal.pone.0090117
    9. Konrath, F., Witt, J., Sauter, T., & Kulms, D. (2014). Identification of New IκBα Complexes by an Iterative Experimental and Mathematical Modeling Approach. PLoS Computational Biology, 10(3), e1003528. https://doi.org/10.1371/journal.pcbi.1003528
    10. Kermer, V., Hornig, N., Harder, M., Bondarieva, A., Kontermann, R. E., & Muller, D. (2014). Combining Antibody-Directed Presentation of IL-15 and 4-1BBL in a Trifunctional Fusion Protein for Cancer Immunotherapy. Molecular Cancer Therapeutics, 13(1), 112--121. https://doi.org/10.1158/1535-7163.MCT-13-0282
    11. Seifert, O., Plappert, A., Fellermeier, S., Siegemund, M., Pfizenmaier, K., & Kontermann, R. E. (2014). Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties. Molecular Cancer Therapeutics, 13(1), 101--111. https://doi.org/10.1158/1535-7163.MCT-13-0396
    12. Barras, D., Chevalier, N., Zoete, V., Dempsey, R., Lapouge, K., Olayioye, M. A., … Widmann, C. (2014). A WXW Motif Is Required for the Anticancer Activity of the TAT-RasGAP317–326 Peptide. Journal of Biological Chemistry, 289(34), 23701--23711. https://doi.org/10.1074/jbc.M114.576272
    13. Neumann, S., Hasenauer, J., Pollak, N., & Scheurich, P. (2014). Dominant negative effects of tumor necrosis factor (tnf)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by Formation of heteromeric complexes. Journal of Biological Chemistry, 289(23), 16576--16587. https://doi.org/10.1074/jbc.M114.559468
    14. Seifert, Oliver, Pollak, N., Nusser, A., Steiniger, F., Rüger, R., Pfizenmaier, K., & Kontermann, R. E. (2014). Immuno-LipoTRAIL: Targeted delivery of TRAIL-functionalized liposomal nanoparticles. Bioconjugate Chemistry, 25(5), 879--887. https://doi.org/10.1021/bc400517j
    15. Lindner, R., Moosmann, A., Dietrich, A., Böttinger, H., Kontermann, R., & Siemann-Herzberg, M. (2014). Process development of periplasmatically produced single chain fragment variable against epidermal growth factor receptor in Escherichia coli. Journal of Biotechnology, 192, 136--145. https://doi.org/10.1016/j.jbiotec.2014.10.003
    16. Moosmann, A., Müller, E., & Böttinger, H. (2014). Purification of PEGylated Proteins, with the example of PEGylated lysozyme and PEGylated scFv. Methods in Molecular Biology, 1129, 527--538. https://doi.org/10.1007/978-1-62703-977-2_37
    17. Raeth, S., Sacchetti, B., Siegel, G., Mau-Holzmann, U. a, Hansmann, J., Vacun, G., … Hausser, A. (2014). A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo. Stem Cells and Development, 23(10), 1097--108. https://doi.org/10.1089/scd.2013.0367
    18. Siegemund, Martin, Richter, F., Seifert, O., Unverdorben, F., & Kontermann, R. E. (2014). Expression and Purification of Recombinant Antibody Formats and Antibody Fusion Proteins. In Methods in Molecular Biology (Clifton, N.J.): Vol. 1131. Methods in molecular biology (Clifton, N.J.) (pp. 273--295). https://doi.org/10.1007/978-1-62703-992-5_18
    19. Bischoff, A., Huck, B., Keller, B., Strotbek, M., Schmid, S., Boerries, M., … Olayioye, M. A. (2014). MiR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion. Cancer Research, 74(18), 5256--5265. https://doi.org/10.1158/0008-5472.CAN-13-3319
    20. Weidle, U. H., Kontermann, R. E., & Brinkmann, U. (2014). Tumor-antigen-binding bispecific antibodies for cancer treatment. Seminars in Oncology, 41(5), 653--660. https://doi.org/10.1053/j.seminoncol.2014.08.004
    21. Huck, B., Duss, S., Hausser, A., & Olayioye, M. A. (2014). Elevated protein kinase D3 (PKD3) expression supports proliferation of Triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. Journal of Biological Chemistry, 289(6), 3138--3147. https://doi.org/10.1074/jbc.M113.502633
    22. Diebolder, P., Keller, A., Haase, S., Schlegelmilch, A., Kiefer, J. D., Karimi, T., … Krauss, J. (2014). Generation of “LYmph Node Derived Antibody Libraries” (LYNDAL) for selecting fully human antibody fragments with therapeutic potential. MAbs, 6(1), 130–142. https://doi.org/10.4161/mabs.27236
  7. 2013

    1. Ellwanger, K., & Hausser, A. (2013). Physiological functions of protein kinase D in vivo. IUBMB Life, 65(2), 98--107. https://doi.org/10.1002/iub.1116
    2. Wajant, H., Gerspach, J., & Pfizenmaier, K. (2013). Engineering death receptor ligands for cancer therapy. Cancer Letters, 332(2), 163--174. https://doi.org/10.1016/j.canlet.2010.12.019
    3. Kakarla, S., Chow, K. K. H., Mata, M., Shaffer, D. R., Song, X. T., Wu, M. F., … Gottschalk, S. (2013). Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Molecular Therapy, 21(8), 1611--1620. https://doi.org/10.1038/mt.2013.110
    4. Hornig, N., Reinhardt, K., Kermer, V., Kontermann, R. E., & Müller, D. (2013). Evaluating combinations of costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy. Cancer Immunology, Immunotherapy, 62(8), 1369--1380. https://doi.org/10.1007/s00262-013-1441-7
    5. Wahl, K., Siegemund, M., Lehner, F., Vondran, F., Nüssler, A., Länger, F., … Bantel, H. (2013). Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology, 57(2), 625--636. https://doi.org/10.1002/hep.26082
    6. Berger, V., Richter, F., Zettlitz, K., Unverdorben, F., Scheurich, P., Herrmann, A., … Kontermann, R. E. (2013). An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action. Protein Engineering, Design and Selection, 26(10), 581--587. https://doi.org/10.1093/protein/gzt044
    7. Richter, F., Liebig, T., Guenzi, E., Herrmann, A., Scheurich, P., Pfizenmaier, K., & Kontermann, R. E. (2013). Antagonistic TNF receptor one-specific antibody (ATROSAB): Receptor binding and in vitro bioactivity. PLoS ONE, 8(8), e72156. https://doi.org/10.1371/journal.pone.0072156
    8. Olayioye, M. A., Barisic, S., & Hausser, A. (2013). Multi-level control of actin dynamics by protein kinase D. Cellular Signalling, 25(9), 1739--1747. https://doi.org/10.1016/j.cellsig.2013.04.010
    9. Maier, O., Fischer, R., Agresti, C., & Pfizenmaier, K. (2013). TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress. Biochemical and Biophysical Research Communications, 440(2), 336--341. https://doi.org/10.1016/j.bbrc.2013.09.083
    10. Vörsmann, H., Groeber, F., Walles, H., Busch, S., Beissert, S., Walczak, H., & Kulms, D. (2013). Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing. Cell Death and Disease, 4(7), e719--e719. https://doi.org/10.1038/cddis.2013.249
    11. Strotbek, M., Florin, L., Koenitzer, J., Tolstrup, A., Kaufmann, H., Hausser, A., & Olayioye, M. A. (2013). Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells. Metabolic Engineering, 20, 157--166. https://doi.org/10.1016/j.ymben.2013.10.005
    12. Kienzle, C., Eisler, S. A., Villeneuve, J., Brummer, T., Olayioye, M. A., & Hausser, A. (2013). PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Molecular Biology of the Cell, 24(3), 222--233. https://doi.org/10.1091/mbc.E12-03-0198
  8. 2012

    1. Witt, J., Konrath, F., Sawodny, O., Ederer, M., Kulms, D., & Sauter, T. (2012). Analysing the role of UVB-induced translational inhibition and PP2Ac deactivation in NF-κB signalling using a minimal mathematical model. PLoS ONE, 7(7), e40274. https://doi.org/10.1371/journal.pone.0040274
    2. Franz-Wachtel, M., Eisler, S. A., Krug, K., Wahl, S., Carpy, A., Nordheim, A., … Macek, B. (2012). Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells. Molecular & Cellular Proteomics, 11(5), 160--170. https://doi.org/10.1074/mcp.M111.016014
    3. Richter, C., Messerschmidt, S., Holeiter, G., Tepperink, J., Osswald, S., Zappe, A., … Krippner-Heidenreich, A. (2012). The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand. Molecular and Cellular Biology, 32(13), 2515--2529. https://doi.org/10.1128/MCB.06458-11
    4. Kempkes, C., Rattenholl, A., Buddenkotte, J., Strozyk, E., Eberle, J., Hausser, A., … Steinhoff, M. (2012). Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1. Journal of Investigative Dermatology, 132(2), 375--384. https://doi.org/10.1038/jid.2011.314
    5. Hutt, M., Färber-Schwarz, A., Unverdorben, F., Richter, F., & Kontermann, R. E. (2012). Plasma half-life extension of small recombinant antibodies by fusion to immunoglobulin-binding domains. Journal of Biological Chemistry, 287(7), 4462--4469. https://doi.org/10.1074/jbc.M111.311522
    6. Hornig, N., Kermer, V., Frey, K., Diebolder, P., Kontermann, R. E., & Müller, D. (2012). Combination of a bispecific antibody and costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy. Journal of Immunotherapy, 35(5), 418--429. https://doi.org/10.1097/CJI.0b013e3182594387
    7. Siegemund, M., Pollak, N., Seifert, O., Wahl, K., Hanak, K., Vogel, A., … Pfizenmaier, K. (2012). Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. Cell Death and Disease, 3(4), e295. https://doi.org/10.1038/cddis.2012.29
    8. Daub, M., Waldherr, S., Allgöwer, F., Scheurich, P., & Schneider, G. (2012). Death wins against life in a spatially extended model of the caspase-3/8 feedback loop. BioSystems, 108(1–3), 45--51. https://doi.org/10.1016/j.biosystems.2012.01.006
    9. Winkel, C., Neumann, S., Surulescu, C., & Scheurich, P. (2012). A minimal mathematical model for the initial molecular interactions of death receptor signalling. Mathematical Biosciences and Engineering, 9(3), 663--683. https://doi.org/10.3934/mbe.2012.9.663
    10. Eisler, S. A., Fuchs, Y. F., Pfizenmaier, K., & Hausser, A. (2012). G-PKDrep-live, a genetically encoded FRET reporter to measure PKD activity at the trans-Golgi-network. Biotechnology Journal, 7(1), 148--154. https://doi.org/10.1002/biot.201100273
    11. Müller, D. (2012). Targeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15. OncoImmunology, 1(7), 1213--1214. https://doi.org/10.4161/onci.20824
    12. Lopez-Ramirez, M. A., Fischer, R., Torres-Badillo, C. C., Davies, H. A., Logan, K., Pfizenmaier, K., … Romero, I. A. (2012). Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells. The Journal of Immunology, 189(6), 3130--3139. https://doi.org/10.4049/jimmunol.1103460
    13. Kontermann, R. E. (2012a). Antibody-cytokine fusion proteins. Archives of Biochemistry and Biophysics, 526(2), 194--205. https://doi.org/10.1016/j.abb.2012.03.001
    14. Seifert, Oliver, Plappert, A., Heidel, N., Fellermeier, S., Messerschmidt, S. K. E., Richter, F., & Kontermann, R. E. (2012). The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity. Protein Engineering, Design and Selection, 25(10), 603--612. https://doi.org/10.1093/protein/gzs059
    15. Heering, J., Weis, N., Holeiter, M., Neugart, F., Staebler, A., Fehm, T. N., … Olayioye, M. A. (2012). Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. Cancer Research, 72(11), 2855--2866. https://doi.org/10.1158/0008-5472.CAN-11-3069
    16. Kontermann, R. E. (2012b). Dual targeting strategies with bispecific antibodies. MAbs, 4(2), 182--197. https://doi.org/10.4161/mabs.4.2.19000
    17. Schildknecht, S., Kirner, S., Henn, A., Gasparic, K., Pape, R., Efremova, L., … Leist, M. (2012). Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions. Altex, 29(3), 261--274. https://doi.org/10.14573/altex.2012.3.261
    18. Moosmann, A., Gerlach, E., Lindner, R., & Böttinger, H. (2012). Purification of a PEGylated single chain Fv. Journal of Chromatography A, 1236, 90--96. https://doi.org/10.1016/j.chroma.2012.03.004
    19. Olayioye, M. A., & Hausser, A. (2012). Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1821(8), 1096--1103. https://doi.org/10.1016/j.bbalip.2011.12.005
    20. Hasenauer, Jan, Heinrich, J., Doszczak, M., Scheurich, P., Weiskopf, D., & Allgöwer, F. (2012). A visual analytics approach for models of heterogeneous cell populations. Eurasip Journal on Bioinformatics and Systems Biology, 2012(1), 4. https://doi.org/10.1186/1687-4153-2012-4
    21. Kermer, Vanessa, Baum, V., Hornig, N., Kontermann, R. E., & Müller, D. (2012). An Antibody Fusion Protein for Cancer Immunotherapy Mimicking IL-15 \textlessi\textgreatertrans\textless/i\textgreater -Presentation at the Tumor Site. Molecular Cancer Therapeutics, 11(6), 1279--1288. https://doi.org/10.1158/1535-7163.MCT-12-0019
    22. Holeiter, G., Bischoff, A., Braun, A. C., Huck, B., Erlmann, P., Schmid, S., … Olayioye, M. A. (2012). The RhoGAP protein deleted in liver cancer 3 (DLC3) is essential for adherens junctions integrity. Oncogenesis, 1(6), e13--e13. https://doi.org/10.1038/oncsis.2012.13
    23. Huck, B., Kemkemer, R., Franz-Wachtel, M., Macek, B., Hausser, A., & Olayioye, M. A. (2012). GIT1 Phosphorylation on Serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. Journal of Biological Chemistry, 287(41), 34604--34613. https://doi.org/10.1074/jbc.M112.374652
    24. Unverdorben, F., Färber-Schwarz, A., Richter, F., Hutt, M., & Kontermann, R. E. (2012). Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A. Protein Engineering, Design and Selection, 25(2), 81--88. https://doi.org/10.1093/protein/gzr061
    25. Neumann, S., Bidon, T., Branschädel, M., Krippner-Heidenreich, A., Scheurich, P., & Doszczak, M. (2012). The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. PLoS ONE, 7(8), e42526. https://doi.org/10.1371/journal.pone.0042526
    26. Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes. Antibodies, 1(3), 199--214. https://doi.org/10.3390/antib1020199
  9. 2011

    1. Krenz, B., Neugart, F., Kleinow, T., & Jeske, H. (2011). Self-interaction of Abutilon mosaic virus replication initiator protein (Rep) in plant cell nuclei. Virus Research, 161(2), 194--197. https://doi.org/10.1016/j.virusres.2011.07.020
    2. Kontermann, R. E. (2011). Strategies for extended serum half-life of protein therapeutics. Current Opinion in Biotechnology, 22(6), 868--876. https://doi.org/10.1016/j.copbio.2011.06.012
    3. Gerspach, Jeannette, Pfizenmaier, K., & Wajant, H. (2011). Therapeutic Targeting of CD95 and the TRAIL Death Receptors. Recent Patents on Anti-Cancer Drug Discovery, 6(3), 294--310. https://doi.org/10.2174/157489211796957739
    4. Pfizenmaier, K., & Szymkowski, D. E. (2011). Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family. Adv Exp Med Biol, 691, 487--491. https://doi.org/10.1007/978-1-4419-6612-4_50
    5. Barisić, S., Nagel, A. C., Franz-Wachtel, M., MacEk, B., Preiss, A., Link, G., … Hausser, A. (2011). Phosphorylation of ser 402 impedes phosphatase activity of slingshot 1. EMBO Reports, 12(6), 527--533. https://doi.org/10.1038/embor.2011.53
    6. Chertoff, M., Paolo, N. D., Schoeneberg, A., Depino, A., Ferrari, C., Wurst, W., … Pitossi, F. (2011). Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice. Experimental Neurology, 227(2), 237--251. https://doi.org/10.1016/j.expneurol.2010.11.010
    7. Schliemann, M., Bullinger, E., Borchers, S., Allgöwer, F., Findeisen, R., & Scheurich, P. (2011). Heterogeneity reduces sensitivity of cell death for TNF-Stimuli. BMC Systems Biology, 5, 204. https://doi.org/10.1186/1752-0509-5-204
    8. Gerspach, Jeannette, Schneider, B., Müller, N., Otz, T., Wajant, H., & Pfizenmaier, K. (2011). Genetic engineering of death ligands for improvement of therapeutic activity. Advances in Experimental Medicine and Biology, 691, 507--519. https://doi.org/10.1007/978-1-4419-6612-4_53
    9. Scholz, R. P., Gustafsson, J. O. R., Hoffmann, P., Jaiswal, M., Ahmadian, M. R., Eisler, S. A., … Olayioye, M. A. (2011). The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Experimental Cell Research, 317(4), 496--503. https://doi.org/10.1016/j.yexcr.2010.11.003
    10. Wajant, H., & Scheurich, P. (2011). TNFR1-induced activation of the classical NF-κB pathway. FEBS Journal, 278(6), 862--876. https://doi.org/10.1111/j.1742-4658.2011.08015.x
    11. Dengler, M. A., Staiger, A. M., Gutekunst, M., Hofmann, U., Doszczak, M., Scheurich, P., … van der Kuip, H. (2011). Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis. PLoS ONE, 6(9), e25139. https://doi.org/10.1371/journal.pone.0025139
    12. Hörnle, M., Peters, N., Thayaparasingham, B., Vörsmann, H., Kashkar, H., & Kulms, D. (2011). Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene, 30(5), 575--587. https://doi.org/10.1038/onc.2010.434
    13. Ziegler, S., Eiseler, T., Scholz, R.-P., Beck, A., Link, G., & Hausser, A. (2011). A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration. Molecular Biology of the Cell, 22(5), 570--580. https://doi.org/10.1091/mbc.E10-05-0427
    14. Ranzinger, J., Rustom, A., Abel, M., Leyh, J., Kihm, L., Witkowski, M., … Schwenger, V. (2011). Nanotube action between human mesothelial cells reveals novel aspects of inflammatory responses. PLoS ONE, 6(12), e29537. https://doi.org/10.1371/journal.pone.0029537
    15. Moosmann, A., Blath, J., Lindner, R., Müller, E., & Böttinger, H. (2011). Aldehyde PEGylation kinetics: A standard protein versus a pharmaceutically relevant single chain variable fragment. Bioconjugate Chemistry, 22(8), 1545--1558. https://doi.org/10.1021/bc200090x
    16. Hasenauer, Jan, Waldherr, S., Doszczak, M., Radde, N., Scheurich, P., & Allgöwer, F. (2011). Identification of models of heterogeneous cell populations from population snapshot data. BMC Bioinformatics, 12, 125. https://doi.org/10.1186/1471-2105-12-125
    17. Gehrmann, M., Doß, B. T., Wagner, M., Zettlitz, K. A., Kontermann, R. E., Foulds, G., … Multhoff, G. (2011). A novel expression and purification system for the production of enzymatic and biologically active human granzyme B. Journal of Immunological Methods, 371(1–2), 8--17. https://doi.org/10.1016/j.jim.2011.06.007
    18. Niessner, H., Beck, D., Sinnberg, T., Lasithiotakis, K., MacZey, E., Gogel, J., … Meier, F. (2011). The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells. Journal of Investigative Dermatology, 131(2), 468--479. https://doi.org/10.1038/jid.2010.297
    19. Witt, J., Barisic, S., Sawodny, O., Ederer, M., Kulms, D., & Sauter, T. (2011). Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation. EURASIP Journal on Bioinformatics & Systems Biology, 2011(1), 3. https://doi.org/10.1186/1687-4153-2011-3
    20. Fischer, R., Maier, O., Siegemund, M., Wajant, H., Scheurich, P., & Pfizenmaier, K. (2011). A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. PLoS ONE, 6(11), e27621. https://doi.org/10.1371/journal.pone.0027621
    21. Fischer, R., Maier, O., Naumer, M., Krippner-Heidenreich, A., Scheurich, P., & Pfizenmaier, K. (2011). Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway. Cellular Signalling, 23(1), 161--170. https://doi.org/10.1016/j.cellsig.2010.08.016
    22. Ellwanger, K., Kienzle, C., Lutz, S., Jin, Z., Wiekowski, M. T., Pfizenmaier, K., & Hausser, A. (2011). Protein kinase D controls voluntary-running-induced skeletal muscle remodelling. Biochemical Journal, 440(3), 327--324. https://doi.org/10.1042/BJ20101980
  10. 2010

    1. Schneider, B., Münkel, S., Krippner-Heidenreich, A., Grunwald, I., Wels, W. S., Wajant, H., … Gerspach, J. (2010). Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins. Cell Death and Disease, 1(8), e68. https://doi.org/10.1038/cddis.2010.45
    2. Becker, E., Florin, L., Pfizenmaier, K., & Kaufmann, H. (2010). Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells. Journal of Biotechnology, 146(4), 198--206. https://doi.org/10.1016/j.jbiotec.2009.11.018
    3. Müller, E., Josic, D., Schröder, T., & Moosmann, A. (2010). Solubility and binding properties of PEGylated lysozyme derivatives with increasing molecular weight on hydrophobic-interaction chromatographic resins. Journal of Chromatography A, 1217(28), 4696--4703. https://doi.org/10.1016/j.chroma.2010.05.016
    4. Zettlitz, K. A., Lorenz, V., Landauer, K., Münkel, S., Herrmann, A., Scheurich, P., … Kontermann, R. E. (2010). ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody. MAbs, 2(6), 639--647. https://doi.org/10.4161/mabs.2.6.13583
    5. Gerken, M., Krippner-Heidenreich, A., Steinert, S., Willi, S., Neugart, F., Zappe, A., … Scheurich, P. (2010). Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors. Biochimica et Biophysica Acta - Biomembranes, 1798(6), 1081--1089. https://doi.org/10.1016/j.bbamem.2010.02.021
    6. Barisic, Sandra, Schmidt, C., Walczak, H., & Kulms, D. (2010). Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFκB activation via Src-dependent blockade of PP2A. Biochemical Pharmacology, 80(4), 439--447. https://doi.org/10.1016/j.bcp.2010.04.028
    7. Murphy, N. C., Biankin, A. V., Millar, E. K. A., McNeil, C. M., O’Toole, S. A., Segara, D., … Sutherland, R. L. (2010). Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status. International Journal of Cancer, 126(6), 1445--1453. https://doi.org/10.1002/ijc.24826
    8. Branschädel, M., Aird, A., Zappe, A., Tietz, C., Krippner-Heidenreich, A., & Scheurich, P. (2010). Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: Conformational stabilization of CRD2 and control of receptor responsiveness. Cellular Signalling, 22(3), 404--414. https://doi.org/10.1016/j.cellsig.2009.10.011
    9. Hasenauer, J., Waldherr, S., Radde, N., Doszczak, M., Scheurich, P., & Allgöwer, F. (2010). A maximum likelihood estimator for parameter distributions in heterogeneous cell populations. Procedia Computer Science, 1(1), 1655--1663. https://doi.org/10.1016/j.procs.2010.04.185
    10. Baum, P., Fundel-Clemens, K., Kreuz, S., Kontermann, R. E., Weith, A., Mennerich, D., & Rippmann, J. F. (2010). Off-target analysis of control siRNA molecules reveals important differences in the cytokine profile and inflammation response of human fibroblasts. Oligonucleotides, 20(1), 17--26. https://doi.org/10.1089/oli.2009.0213
    11. Baum, P., Schmid, R., Ittrich, C., Rust, W., Fundel-Clemens, K., Siewert, S., … Mennerich, D. (2010). Phenocopy - a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization. PLoS ONE, 5(12), 1--15. https://doi.org/10.1371/journal.pone.0014272
    12. Eiseler, T., Hausser, A., De Kimpe, L., Van Lint, J., & Pfizenmaier, K. (2010). Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. Journal of Biological Chemistry, 285(24), 18672--18683. https://doi.org/10.1074/jbc.M109.093880
    13. Waldherr, S., Hasenauer, J., Doszczak, M., Scheurich, P., & Allgöwer, F. (2010). Global uncertainty analysis for a model of TNF-induced NF-κB signalling. In Lecture Notes in Control and Information Sciences: Vol. 407. Lecture Notes in Control and Information Sciences (pp. 365--377). https://doi.org/10.1007/978-3-642-16135-3-29
    14. Müller, D., & Kontermann, R. E. (2010). Bispecific antibodies for cancer immunotherapy: Current perspectives. BioDrugs, 24(2), 89--98. https://doi.org/10.2165/11530960-000000000-00000
    15. Brandt, S., Ellwanger, K., Beuter-Gunia, C., Schuster, M., Hausser, A., Schmitz, I., & Beer-Hammer, S. (2010). SLy2 targets the nuclear SAP30/HDAC1 complex. International Journal of Biochemistry and Cell Biology, 42(9), 1472--1481. https://doi.org/10.1016/j.biocel.2010.05.004
    16. Hopp, J., Hornig, N., Zettlitz, K. A., Schwarz, A., Fuß, N., Müller, D., & Kontermann, R. E. (2010). The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein. Protein Engineering, Design and Selection, 23(11), 827--834. https://doi.org/10.1093/protein/gzq058
    17. Zettlitz, K. A., Seitter, J., Müller, D., & Kontermann, R. E. (2010). Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70). Molecular Biotechnology, 46(3), 265--278. https://doi.org/10.1007/s12033-010-9298-x
    18. Hasenauer, J., Waldherr, S., Doszczak, M., Scheurich, P., & Allgöwer, F. (2010). Density-based modeling and identification of biochemical networks in cell populations. IFAC Proceedings Volumes (IFAC-PapersOnline), 9(PART 1), 320--325. https://doi.org/10.3182/20100705-3-BE-2011.0038
    19. Rothdiener, M., Müller, D., Castro, P. G., Scholz, A., Schwemmlein, M., Fey, G., … Kontermann, R. E. (2010). Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems. Journal of Controlled Release, 144(2), 251--258. https://doi.org/10.1016/j.jconrel.2010.02.020
    20. Smolders, I., Smets, I., Maier, O., VandeVen, M., Steels, P., & Ameloot, M. (2010). Simvastatin interferes with process outgrowth and branching of oligodendrocytes. Journal of Neuroscience Research, 88(15), 3361--3375. https://doi.org/10.1002/jnr.22490
    21. Moosmann, A., Christel, J., Boettinger, H., & Mueller, E. (2010). Analytical and preparative separation of PEGylated lysozyme for the characterization of chromatography media. Journal of Chromatography A, 1217(2), 209--215. https://doi.org/10.1016/j.chroma.2009.11.031
    22. Boschert, V., Krippner-Heidenreich, A., Branschädel, M., Tepperink, J., Aird, A., & Scheurich, P. (2010). Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2. Cellular Signalling, 22(7), 1088--1096. https://doi.org/10.1016/j.cellsig.2010.02.011
    23. Anliker, B., Abel, T., Kneissl, S., Hlavaty, J., Caputi, A., Brynza, J., … Buchholz, C. J. (2010). Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nature Methods, 7, 929--. Retrieved from http://dx.doi.org/10.1038/nmeth.1514
    24. Kontermann, R. E. (2010). Alternative antibody formats. Current Opinion in Molecular Therapeutics, 12(2), 176--183. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20373261
    25. Rothdiener, M., Beuttler, J., Messerschmidt, S. K., & Kontermann, R. E. (2010). Antibody targeting of nanoparticles to tumor-specific receptors: immunoliposomes. Methods in Molecular Biology (Clifton, N.J.), 624, 295--308. https://doi.org/10.1007/978-1-60761-609-2_20
    26. Joffroy, C. M., Buck, M. B., Stope, M. B., Popp, S. L., Pfizenmaier, K., & Knabbe, C. (2010). Antiestrogens induce transforming growth factor $\beta$-mediated immunosuppression in breast cancer. Cancer Research, 70(4), 1314--1322. https://doi.org/10.1158/0008-5472.CAN-09-3292
  11. 2009

    1. Schlatter, R., Schmich, K., Vizcarra, I. A., Scheurich, P., Sauter, T., Borner, C., … Sawodny, O. (2009). ON/OFF and beyond - A Boolean model of apoptosis. PLoS Computational Biology, 5(12), e1000595. https://doi.org/10.1371/journal.pcbi.1000595
    2. Beuttler, J., Rothdiener, M., Müller, D., Frejd, F. Y., & Kontermann, R. E. (2009). Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL). Bioconjugate Chemistry, 20(6), 1201–1208. https://doi.org/10.1021/bc900061v
    3. Ranzinger, J., Krippner-Heidenreich, A., Haraszti, T., Bock, E., Tepperink, J., Spatz, J. P., & Scheurich, P. (2009). Nanoscale arrangement of apoptotic ligands reveals a demand for a minimal lateral distance for efficient death receptor activation. Nano Letters, 9(12), 4240--4245. https://doi.org/10.1021/nl902429b
    4. Gerspach, Jeannette, Wajant, H., & Pfizenmaier, K. (2009). Death ligands designed to kill: Development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands. Results and Problems in Cell Differentiation, 49, 241--273. https://doi.org/10.1007/400_2008_22
    5. Gerspach, Jeannette, Pfizenmaier, K., & Wajant, H. (2009). Improving TNF as a cancer therapeutic: Tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects. BioFactors, 35(4), 364--372. https://doi.org/10.1002/biof.50
    6. Erlmann, P., Schmid, S., Horenkamp, F. A., Geyer, M., Pomorski, T. G., & Olayioye, M. A. (2009). DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain. Molecular Biology of the Cell, 20(20), 4400--4411. https://doi.org/10.1091/mbc.E09-03-0247
    7. Sinnberg, T., Lasithiotakis, K., Niessner, H., Schittek, B., Flaherty, K. T., Kulms, D., … Meier, F. (2009). Inhibition of PI3K-AKT-mTOR Signaling Sensitizes Melanoma Cells to Cisplatin and Temozolomide. Journal of Investigative Dermatology, 129(6), 1500--1515. https://doi.org/10.1038/jid.2008.379
    8. Thayaparasingham, B., Kunz, A., & Kulms, D. (2009). Sensitization of melanoma cells to TRAIL by UVB-induced and NF-κB-mediated downregulation of xIAP. Oncogene, 28(3), 345--362. https://doi.org/10.1038/onc.2008.397
    9. Kontermann, R. E. (2009). Strategies to extend plasma half-lives of recombinant antibodies. BioDrugs, 23(2), 93--109. https://doi.org/10.2165/00063030-200923020-00003
    10. Messerschmidt, Sylvia K.E., Musyanovych, A., Altvater, M., Scheurich, P., Pfizenmaier, K., Landfester, K., & Kontermann, R. E. (2009). Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells. Journal of Controlled Release, 137(1), 69--77. https://doi.org/10.1016/j.jconrel.2009.03.010
    11. Peterburs, P., Heering, J., Link, G., Pfizenmaier, K., Olayioye, M. A., & Hausser, A. (2009). Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Research, 69(14), 5634--5638. https://doi.org/10.1158/0008-5472.CAN-09-0718
    12. Wicovsky, A., Henkler, F., Salzmann, S., Scheurich, P., Kneitz, C., & Wajant, H. (2009). Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene, 28(15), 1769--1781. https://doi.org/10.1038/onc.2009.29
    13. Czöndör, K., Ellwanger, K., Fuchs, Y. F., Lutz, S., Gulyás, M., Mansuy, I. M., … Schlett, K. (2009). Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Molecular Biology of the Cell, 20(7), 2108--20. https://doi.org/10.1091/mbc.E08-09-0957
    14. Florin, L., Pegel, A., Becker, E., Hausser, A., Olayioye, M. A., & Kaufmann, H. (2009). Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells. Journal of Biotechnology, 141(1–2), 84--90. https://doi.org/10.1016/j.jbiotec.2009.02.014
    15. Fuchs, Y. F., Eisler, S. A., Link, G., Schlicker, O., Bunt, G., Pfizenmaier, K., & Hausser, A. (2009). A Golgi PKD activity reporter reveals a crucial role of PKD in nocodazole-induced Golgi dispersal. Traffic, 10(7), 858--867. https://doi.org/10.1111/j.1600-0854.2009.00918.x
    16. Stork, R., Campigna, E., Robert, B., Müller, D., & Kontermann, R. E. (2009). Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. Journal of Biological Chemistry, 284(38), 25612--25619. https://doi.org/10.1074/jbc.M109.027078
    17. Wyzgol, A., Muller, N., Fick, A., Munkel, S., Grigoleit, G. U., Pfizenmaier, K., & Wajant, H. (2009). Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand. The Journal of Immunology, 183(3), 1851--1861. https://doi.org/10.4049/jimmunol.0802597
    18. Kontermann, R. E., Scheurich, P., & Pfizenmaier, K. (2009). Antagonists of TNF action: clinical experience and new developments. Expert Opinion on Drug Discovery, 4(3), 279--292. https://doi.org/10.1517/17460440902785167
    19. Heering, J., Erlmann, P., & Olayioye, M. A. (2009). Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration. Experimental Cell Research, 315(15), 2505--2514. https://doi.org/10.1016/j.yexcr.2009.05.022
    20. Witt, J., Barisic, S., Schumann, E., Allgöwer, F., Sawodny, O., Sauter, T., & Kulms, D. (2009). Mechanism of PP2A-mediated IKKβ dephosphorylation: A systems biological approach. BMC Systems Biology, 3, 71. https://doi.org/10.1186/1752-0509-3-71
    21. Ahmadvand, D., Rasaee, M. J., Rahbarizadeh, F., Kontermann, R. E., & Sheikholislami, F. (2009). Cell selection and characterization of a novel human endothelial cell specific nanobody. Molecular Immunology, 46(8–9), 1814--1823. https://doi.org/10.1016/j.molimm.2009.01.021
    22. Scholz, R.-P., Regner, J., Theil, A., Erlmann, P., Holeiter, G., Jähne, R., … Olayioye, M. a. (2009). DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. Journal of Cell Science, 122(Pt 1), 92--102. https://doi.org/10.1242/jcs.036251
    23. Breindl, C., Waldherr, S., Hausser, A., & Allgöwer, F. (2009). MODELING COFILIN MEDIATED REGULATION OF CELL MIGRATION AS A BIOCHEMICAL TWO-INPUT SWITCH. Proc.of the 3rd Foundations of Systems Biology in Engineering (FOSBE), 60--63. Retrieved from https://lirias.kuleuven.be/bitstream/123456789/568203/1/BreindlWal2009.pdf
    24. Cowell, C. F., Doppler, H., Yan, I. K., Hausser, A., Umezawa, Y., & Storz, P. (2009). Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling. Journal of Cell Science, 122(7), 919--928. https://doi.org/10.1242/jcs.041061
  12. 2008

    1. Holeiter, Gerlinde, Heering, J., Erlmann, P., Schmid, S., Jähne, R., & Olayioye, M. A. (2008). Deleted in liver cancer 1 controls cell migration through a dia1-dependent signaling pathway. Cancer Research, 68(21), 8743--8751. https://doi.org/10.1158/0008-5472.CAN-08-0984
    2. Kontermann, R. E., Münkel, S., Neumeyer, J., Müller, D., Branschädel, M., Scheurich, P., & Pfizenmaier, K. (2008). A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action. Journal of Immunotherapy, 31(3), 225--234. https://doi.org/10.1097/CJI.0b013e31816a88f9
    3. Ellwanger, K., Pfizenmaier, K., Lutz, S., & Hausser, A. (2008). Expression patterns of protein kinase D 3 during mouse development. BMC Developmental Biology, 8, 47. https://doi.org/10.1186/1471-213X-8-47
    4. Stork, R., Zettlitz, K. A., Müller, D., Rether, M., Hanisch, F. G., & Kontermann, R. E. (2008). N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies. Journal of Biological Chemistry, 283(12), 7804--7812. https://doi.org/10.1074/jbc.M709179200
    5. Singer-Krüger, B., Lasić, M., Bürger, A. M., Haußer, A., Pipkorn, R., & Wang, Y. (2008). Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. EMBO Journal, 27(10), 1423--1435. https://doi.org/10.1038/emboj.2008.75
    6. Barisic, S., Strozyk, E., Peters, N., Walczak, H., & Kulms, D. (2008). Identification of PP2A as a crucial regulator of the NF-$\kappa$B feedback loop: Its inhibition by UVB turns NF-κB into a pro-apoptotic factor. Cell Death and Differentiation, 15(11), 1681--1690. https://doi.org/10.1038/cdd.2008.98
    7. Chang, H. H., Wang, W., Bong, S. J., Wong, C., Hausser, A., Pfizenmaier, K., … Jin, Z. G. (2008). Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. Journal of Biological Chemistry, 283(21), 14590--14599. https://doi.org/10.1074/jbc.M800264200
    8. Krippner-Heidenreich, A., Grunwald, I., Zimmermann, G., Kuhnle, M., Gerspach, J., Sterns, T., … Scheurich, P. (2008). Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity. The Journal of Immunology, 180(12), 8176--8183. https://doi.org/10.4049/jimmunol.180.12.8176
    9. Müller, N., Wyzgol, A., Münkel, S., Pfizenmaier, K., & Wajant, H. (2008). Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. FEBS Journal, 275(9), 2296--2304. https://doi.org/10.1111/j.1742-4658.2008.06382.x
    10. Messerschmidt, S. K E, Kolbe, A., Müller, D., Knoll, M., Pleiss, J., & Kontermann, R. E. (2008). Novel single-chain Fv′ formats for the generation of immunoliposomes by site-directed coupling. Bioconjugate Chemistry, 19(1), 362--369. https://doi.org/10.1021/bc700349k
    11. Müller, D., Frey, K., & Kontermann, R. E. (2008). A novel antibody-4-1BBL fusion protein for targeted costimulation in cancer immunotherapy. Journal of Immunotherapy, 31(8), 714--722. https://doi.org/10.1097/CJI.0b013e31818353e9
    12. Müller, D., Trunk, G., Sichelstiel, A., Zettlitz, K. A., Quintanilla, M., & Kontermann, R. E. (2008). Murine endoglin-specific single-chain Fv fragments for the analysis of vascular targeting strategies in mice. Journal of Immunological Methods, 339(1), 90--98. https://doi.org/10.1016/j.jim.2008.08.008
    13. Müller, E., & Faude, A. (2008). Investigation of salt properties with electro-acoustic measurements and their effect on dynamic binding capacity in hydrophobic interaction chromatography. Journal of Chromatography A, 1177(2), 215--225. https://doi.org/10.1016/j.chroma.2007.11.008
    14. Lasithiotakis, K. G., Sinnberg, T. W., Schittek, B., Flaherty, K. T., Kulms, D., Maczey, E., … Meier, F. E. (2008). Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells. Journal of Investigative Dermatology, 128(8), 2013--2023. https://doi.org/10.1038/jid.2008.44
    15. Johnson, T. S., Mahnke, K., Storn, V., Schönfeld, K., Ring, S., Nettelbeck, D. M., … Enk, A. H. (2008). Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC-205 single-chain fragment variable molecule. Clinical Cancer Research, 14(24), 8169--8177. https://doi.org/10.1158/1078-0432.CCR-08-1474
    16. BECKER, E., FLORIN, L., PFIZENMAIER, K., & KAUFMANN, H. (2008). An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes. Journal of Biotechnology, 135(2), 217--223. https://doi.org/10.1016/j.jbiotec.2008.03.008
  13. 2007

    1. Olayioye, M. A., Buchholz, M., Schmid, S., Schöffler, P., Hoffmann, P., & Pomorski, T. (2007). Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. Journal of Biological Chemistry, 282(31), 22492--22498. https://doi.org/10.1074/jbc.M701990200
    2. Eissing, T., Waldherr, S., Allgöwer, F., Scheurich, P., & Bullinger, E. (2007). Response to bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophysical Journal, 92(9), 3332--3334. https://doi.org/10.1529/biophysj.106.100362
    3. Eiseler, T., Schmid, M. A., Topbas, F., Pfizenmaier, K., & Hausser, A. (2007). PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Letters, 581(22), 4279--4287. https://doi.org/10.1016/j.febslet.2007.07.079
    4. Baum, P., Müller, D., Rüger, R., & Kontermann, R. E. (2007). Single-chain Fv immunoliposomes for the targeting of fibroblast activation protein-expressing tumor stromal cells. Journal of Drug Targeting, 15(6), 399--406. https://doi.org/10.1080/10611860701453034
    5. Eißing, T., Waldherr, S., Allgöwer, F., Scheurich, P., & Bullinger, E. (2007). Steady state and (bi-) stability evaluation of simple protease signalling networks. Biosystems, 90(3), 591--601. https://doi.org/10.1016/j.biosystems.2007.01.003
    6. Berg, D., Lehne, M., Müller, N., Siegmund, D., Münkel, S., Sebald, W., … Wajant, H. (2007). Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death and Differentiation, 14(12), 2021--2034. https://doi.org/10.1038/sj.cdd.4402213
    7. Stork, R., Müller, D., & Kontermann, R. E. (2007). A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Engineering, Design and Selection, 20(11), 569--576. https://doi.org/10.1093/protein/gzm061
    8. Fugmann, T., Hausser, A., Schöffler, P., Schmid, S., Pfizenmaier, K., & Olayioye, M. A. (2007). Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. Journal of Cell Biology, 178(1), 15--22. https://doi.org/10.1083/jcb.200612017
    9. Faude, A., Zacher, D., Müller, E., & Böttinger, H. (2007). Fast determination of conditions for maximum dynamic capacity in cation-exchange chromatography of human monoclonal antibodies. Journal of Chromatography A, 1161(1–2), 29--35. https://doi.org/10.1016/j.chroma.2007.03.114
    10. Xu, X., Ha, C. H., Wong, C., Wang, W., Hausser, A., Pfizenmaier, K., … Jin, Z. G. (2007). Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(11), 2355--2362. https://doi.org/10.1161/ATVBAHA.107.151704
    11. Witt, J., Husser, S., Kulms, D., Barisic, S., Sawodny, O., & Sauter, T. (2007). Modeling of IL-1 induced NF-κB signaling and analysis of additional UVB influence. Proceedings of the SICE Annual Conference, 1353--1358. https://doi.org/10.1109/SICE.2007.4421193
    12. Maier, D., Nagel, A. C., Gloc, H., Hausser, A., Kugler, S. J., Wech, I., & Preiss, A. (2007). Protein Kinase D regulates several aspects of development in Drosophila melanogaster. BMC Developmental Biology, 7, 74. https://doi.org/10.1186/1471-213X-7-74
    13. Meier, F., Busch, S., Lasithiotakis, K., Kulms, D., Garbe, C., Maczey, E., … Schittek, B. (2007). Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. British Journal of Dermatology, 156(6), 1204--1213. https://doi.org/10.1111/j.1365-2133.2007.07821.x
    14. Müller, D., & Kontermann, R. E. (2007). Recombinant bispecific antibodies for cellular cancer immunotherapy. Current Opinion in Molecular Therapeutics, 9(4), 319. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17694444
    15. Hesse, A., Kosmides, D., Kontermann, R. E., & Nettelbeck, D. M. (2007). Tropism Modification of Adenovirus Vectors by Peptide Ligand Insertion into Various Positions of the Adenovirus Serotype 41 Short-Fiber Knob Domain. Journal of Virology, 81(6), 2688--2699. https://doi.org/10.1128/JVI.02722-06
    16. Müller, D., Karle, A., Meißburger, B., Höfig, I., Stork, R., & Kontermann, R. E. (2007). Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. Journal of Biological Chemistry, 282(17), 12650--12660. https://doi.org/10.1074/jbc.M700820200
  14. 2006

    1. Kulms, D., & Schwarz, T. (2006). NF-κB and Cytokines. Vitamins and Hormones, 74, 283--300. https://doi.org/10.1016/S0083-6729(06)74011-0
    2. Hausser, A., Link, G., Hoene, M., Russo, C., Selchow, O., & Pfizenmaier, K. (2006). Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III β protects from dephosphorylation and stabilizes lipid kinase activity. Journal of Cell Science, 119(17), 3613--3621. https://doi.org/10.1242/jcs.03104
    3. Kontermann, R. E. (2006). Immunoliposomes for cancer therapy. Current Opinion in Molecular Therapeutics, 8(1), 39--45. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16506524
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