Prof. Markus Morrison (Rehm) - Cell Biology and Applied Systems Biology
The group aims to obtain unprecedented mechanistic insight into intra- and inter-cellular signalling processes that modulate cell fate decisions between life and death. To this end we apply a broad portfolio of cell biological, biochemical, biophysical and systems biological approaches.
Prof. Monilola Olayioye - Molecular Tumor Biology
We are interested in the functional contribution of specific oncogenes and tumor suppressors to cellular transformation, with a focus on breast tumorigenesis. We are studying membrane-proximal signaling events that control cell proliferation, migration and invasion.
Prof. Roland Kontermann - Biomedical Engineering
Our research interests focus on the development of recombinant antibodies (small bispecific and bifunctional antibody molecules, humanized antibodies) with improved biological and pharmacokinetic properties and targeted nanoparticulate carrier systems for cancer therapy.
Dr. Angelika Hausser - Membrane Trafficking and Signalling
We are interested in the physiological functions of Protein Kinase D. Specific projects address the role of PKD and its substrates in secretion and tumor cell migration and invasion using 2D and 3D cell culture systems as well as whole organisms (transgenic mouse models).
Dr. Dafne Müller - Immuno-Oncology
Our research has its focus on the development of combinatorial strategies for cancer immunotherapy in form of targeted approaches involving bispecific antibodies and antibody fusion proteins with immune modulatory ligands and cytokines.
Dr. Roman Fischer - Neuroimmunology
We are interested in the complex biology of the cytokine tumor necrosis factor (TNF) and in unraveling the physiological and pathological responses induced via its receptors, TNFR1 and TNFR2. In particular, we aim to develop novel therapeutic strategies to selectively modulate the activities mediated by TNFR1 and TNFR2.
Dr. Andrew Clark - Cell Biology of the Intestine (joint research group with the University of Tübingen)
Our lab focuses on understanding how the properties and behavior of individual cells in the intestinal epithelium give rise to tissue-scale function. We are interested in collective cell behaviors during homeostasis and how dysregulation of these processes contributes to intestinal pathologies such as inflammatory bowel disease and colorectal cancer.