Research

From the discovery of biological mechanisms to applications and products

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Professor Markus Morrison

Prof. Markus Morrison (Rehm) - Cell Biology and Applied Systems Biology

The group aims to obtain unprecedented mechanistic insight into intra- and inter-cellular signalling processes that modulate cell fate decisions between life and death. To this end we apply a broad portfolio of cell biological, biochemical, biophysical and systems biological approaches.

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Professor Monilola Olayioye

Prof. Monilola Olayioye - Molecular Tumor Biology

We are interested in the functional contribution of specific oncogenes and tumor suppressors to cellular transformation, with a focus on breast tumorigenesis. We are studying membrane-proximal signaling events that control cell proliferation, migration and invasion.

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Professor Roland Kontermann

Prof. Roland Kontermann - Biomedical Engineering

Our research interests focus on the development of recombinant antibodies (small bispecific and bifunctional antibody molecules, humanized antibodies) with improved biological and pharmacokinetic properties and targeted nanoparticulate carrier systems for cancer therapy.

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Dr. Angelika Hausser

Dr. Angelika Hausser - Membrane Trafficking and Signalling

We are interested in the physiological functions of Protein Kinase D. Specific projects address the role of PKD and its substrates in secretion and tumor cell migration and invasion using 2D and 3D cell culture systems as well as whole organisms (transgenic mouse models).

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Dr. Dafne Müller

Dr. Dafne Müller - Oncoimmunology

Our research has its focus on the development of combinatorial strategies for cancer immunotherapy in form of targeted approaches involving bispecific antibodies and antibody fusion proteins with immune modulatory ligands and cytokines.

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Professor Klaus Pfizenmaier

Prof. Klaus Pfizenmaier - Cell Biology

The group has a long standing interest in elucidating the biology of ligands of the TNF superfamily including the development of tumor targeted death ligands. Further projects address mechanisms of mesenchymal stem cell propagation and differentiation.

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