Prof. Markus Morrison (Rehm) - Cell Biology and Applied Systems Biology
The group aims to obtain unprecedented mechanistic insight into intra- and inter-cellular signalling processes that modulate cell fate decisions between life and death. To this end we apply a broad portfolio of cell biological, biochemical, biophysical and systems biological approaches.
Prof. Monilola Olayioye - Molecular Tumor Biology
We are interested in the functional contribution of specific oncogenes and tumor suppressors to cellular transformation, with a focus on breast tumorigenesis. We are studying membrane-proximal signaling events that control cell proliferation, migration and invasion.
Prof. Roland Kontermann - Biomedical Engineering
Our research interests focus on the development of recombinant antibodies (small bispecific and bifunctional antibody molecules, humanized antibodies) with improved biological and pharmacokinetic properties and targeted nanoparticulate carrier systems for cancer therapy.
Dr. Angelika Hausser - Membrane Trafficking and Signalling
We are interested in the physiological functions of Protein Kinase D. Specific projects address the role of PKD and its substrates in secretion and tumor cell migration and invasion using 2D and 3D cell culture systems as well as whole organisms (transgenic mouse models).
Dr. Dafne Müller - Oncoimmunology
Our research has its focus on the development of combinatorial strategies for cancer immunotherapy in form of targeted approaches involving bispecific antibodies and antibody fusion proteins with immune modulatory ligands and cytokines.
Prof. Klaus Pfizenmaier - Cell Biology
The group has a long standing interest in elucidating the biology of ligands of the TNF superfamily including the development of tumor targeted death ligands. Further projects address mechanisms of mesenchymal stem cell propagation and differentiation.