27. Juli 2015

Review accepted in Pharmacology and Therapeutics

Antibody fusions with immunomodulatory proteins for cancer therapy

Review accepted in Pharmacology and Therapeutics

 

Pharmacol Ther. 2015 Jul 3. pii: S0163-7258(15)00139-4. doi: 10.1016/j.pharmthera.2015.07.001. [Epub ahead of print]

Antibody fusions with immunomodulatory proteins for cancer therapy

Dafne Müller

 

Abstract

The potential of immunomodulatory proteins, in particular cytokines, for cancer therapy is well recognized, but hampered by the toxicity associated with their systemic application. In order to address this problem, targeted delivery by antibody fusion proteins has been early proposed and their development intensively pursued over the last decade. Here, factors influencing the selection and modification of cytokines and antibody formats for this approach are being discussed, indicating current developments and translational advances in the field.

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