Dr. Oliver Seifert will give a talk on "eIg-Based Bispecific T Cell-Engagers: Format Matters" at the PEGS-Europe.
The eIg platform technology was used to generate a set of bispecific TCEs targeting EGFR and CD3. In total, 11 different TCE formats were analyzed for binding to target and T cells, T cell-mediated killing of tumor cells, and for the activation of T cells. Our findings support that screening of a panel of formats is beneficial to identify the most potent bispecific TCE, and that format matters.