11. Juli 2012

Author´s view article

about targeted cancer immuno-therapy published by Dr. Dafne Müller in OncoImmunology

Accepted for publication in OncoImmunology:

Targeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15


Dafne Müller

Institut für Zellbiologie und Immunologie; Universität Stuttgart; Stuttgart, Germany

Abstract

Under physiological conditions, the trans-presentation of interleukin-15 (IL-15) by the IL-15 receptor α on the cell surface allows to confine and tune the IL-15-mediated immune responses. Therefore, targeting strategies that mimic this situation at the tumor sites appear especially promising for anticancer immunotherapy.

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