Tumor cells are characterized by complex molecular changes that lead to aberrant survival, growth and motility. Our team investigates the interplay of tumor suppressive and oncogenic signaling networks in cellular transformation. A particular focus is on the signaling pathways that contribute to cancer cell metastasis. Using 3D tissue culture models, we study the molecular interactions with the tumor cell environment, aiming to identify new therapeutic points of intervention. We further employ advanced genetic engineering approaches, primary (co)culture models in combination with single cell and state-of-the-art imaging techniques.